Ergonomics are key to a comfortable and healthy workstation. While often overlooked, the mouse is a critical component. For individuals experiencing wrist pain or carpal tunnel, an ergonomic mouse can make a significant difference. Vertical and semi-vertical mice promote a more natural 'handshake' position, reducing strain. Trackball mice minimize shoulder movement. After testing over 20 ergonomic mice, recommendations have been compiled for vertical, semi-vertical, and trackball designs to help users find the best fit for their needs in 2025.